Objective: Multiple sclerosis (MS) is the most common chronic disease of the central nervous system. Its chronic nature, no cure and onset at a young age can have a devastating effect on quality of life and fatigue .This research is The effect of group mindfulness- based stress reduction program and conscious yoga on the quality of life and fatigue in patients with multiple Sclerosis .Methods: A quasi-experimental study with experimental and control groups, respectively. The sampling method initially public call between members of the MS Society in Tehran were held and 24 patients with a diagnosis of MS and having the criteria for inclusion of the applicants were randomly assigned to the experimental group (n = 12) and control group ( n = 12) were assigned. MS patients' quality of life questionnaires (MSQOL-54) and the Fatigue Severity Scale (FSS), the participants before and after treatment was completed. The experimental group in 8 sessions of mindfulness-based stress reduction program 2 hours under treatment and yoga sober for groups. Data were analyzed using covariance single variable. Results: The results showed that the mean scores of some subscales of the quality of life including physical functioning, role in relation to physical and mental energy, mental well-being, health threats, perceived health, satisfaction with sexual function, quality of life and fatigue test and control groups was significant difference (P <0/05).Therefore, using this method of protection, can be used as an effective method to improve the quality of life and fatigue resulting from multiple sclerosis and enabling them to be used.