Sexual dysfunction, especially of erectile dysfunction is a relatively unknown disorder and resistant to treatment. This study aimed to assess effectiveness of cognitive-behavioral therapy on sexual of erectile dysfunction and comorbid psychiatric symptoms was done with it. The research is single-case designs by A-B. 28-year-old man who authorities based on the criteria of the study, the clinical interview based on DSM-V, hospital anxiety and depression scale )HADS), arizona sexual experiences scale (ASEX), international index of erectile dysfunction (IIEF-5) and psychiatrists definitive diagnosis of the disorder. The position of the baseline, the intervention began. participants was exposed to 8 sessions of 90 minute and a month after the intervention sessions, two sets of questionnaires administered in 2 consecutive months and was completed as a follow-up < /font> phase. The results of this study based on the visual analyses indicators and descriptive statistics showed that in the follow-up phase compared to the baseline, the intervention was effective of improve erectile dysfunction, in reduction of comorbidity of depression and anxiety. The results emphasize the importance of this intervention in sexual dysfunction and provide new horizons in clinical interventions emphasized.