Background and Objectives: Attending to psychological state in women with HIV because of strong influence on incidence, progression and prognosis of this disease is very important. The aim of present study was investigating the effectiveness of mind-fullness based cognitive therapy on depression, anxiety, perceived stress and quality of life in women with HIV. Methods  and Materials: This research was semi-experimental with pre-test and post-test and follow-up with control group. In this study, 24 positive HIV women in Tehran city were selected by volunteers sampling method and were randomly assigned to either control group and or MBCT groups and Center for Epidemiologic Studies Depression (CES-D), Zung anxiety scale (SAS), Cohen Perceived Stress (PSS) and World health organization Quality of life questionnaire were administrated as pretest. The MBCT group received 8 sessions of mindfulness based cognitive therapy and the control group received no intervention. At the end, post-test was administrated on two groups and, repeated measure multi-variable was used for data analysis by spss-20 software. Results: The results of the present study indicated that there were significant differences between the experimental groups control group and MBCT (p < 0.001). So that, in MBCT group decrease the mean of depression, anxiety, perceived stress and increase the mean of quality of life. Discussion: Therefore, In order to improve the quality of life and reduce in psychological in these patients, attention to these variables during clinical trials with the goal of appropriate intervention will be beneficial.