Autism is a disorder of aberrant behaviors such as stereotyped behaviors, impaired communication and social interaction. On the other hand, the family plays a fundamental role in ensuring children health and welfare, learning how to deal with maladaptive behaviors of autistic children are important to parents. This study examined the effectiveness of psychological interventions, family-centered, child-centered and a combination of reduced symptoms of autistic children in real life. The research method is experience with pre-test - post-test design and control group. From autistic children rehabilitation centers in Isfahan, 12 autistic children with their parents were chosen with cluster sampling according to the research entry criteria and participated in the research. To measure the symptoms of autistic children were used their real-life rating scale. Educational - Consulting Horen B model was used for family-centered interventions and applied analysis behavior method for child-centered interventions. Data analysis was performed by covariance analysis. The results showed that there was a significant difference between the scores of three groups of children who were under psychological interventions of child and family-centered and combination of them and control groups (p≤0 /001). Based on the findings, it can be concluded that the family-centered interventions, child-centered interventions and the combination is effective in reducing symptoms of autistic children. Combined interventions had more effective.